排序方式： 共有11条查询结果，搜索用时 15 毫秒
1.
为建立HPLC法测定牛奶中磺胺类药残留量的方法。样品经乙腈处理沉淀蛋白质后取上清液浓缩,以乙腈-水(体积比为1∶1)为流动相进行高效液相色谱分析。结果表明4种磺胺类药分离效果良好,平均回收率范围81.6%～95.8%,相对标准偏差为1.5%～4.2%,最低检出限达1.0～2.0ng/mL。可见该检测法具有灵敏、准确、精密、无杂质干扰等优点。 相似文献
2.
建立了高效液相色谱—串联质谱法(LC/MS/MS)测定羊肉中残留的6种磺胺类药物:磺胺喹噁啉(sulfaquinoxaline,SQX)、磺胺嘧啶(sulfadiazine,SDZ)、磺胺二甲氧嘧啶(sulfadimethoxine,SDM)、磺胺间甲氧嘧啶(sulfamonomethoxin,SMM)、磺胺对甲氧嘧啶(sulfameter,SMT)、磺胺甲噁唑(sulfamethoxazole,SMZ)。样品经乙腈匀浆提取,正己烷脱脂后旋转蒸发至近干,氮气吹干,流动相溶解并定容,再用正己烷净化后上机检测,在多反应监测模式下检测,外标法定量。结果表明,6种磺胺质量浓度在10～500μg/L内线性关系良好,相关系数R2为0.998 1～0.999 8,回收率为78%～105%,定量限为10μg/kg。 相似文献
3.
The frequency of enterotoxigenic coagulase-positive and coagulase-negative staphylococci in nose and throat and in hand lesions was investigated in 86 meat cutters and dressers. Enterotoxin-producing staphylococci were demonstrated in nasal swabs from 22% of clinically well workers and from 42% of a group with mild coryza. The corresponding rates in throat swabs were 6 and 12%. Four of 16 superficial lesions of the hand harbored enterotoxigenic staphylococci. The implications for contamination of food and outbreaks of staphylococcal food poisoning are discussed. 相似文献
4.
L Blom 《Acta veterinaria Scandinavica》1975,16(3):396-404
Drug residues in blood plasma, egg-white and -yolk have been measured for 3 weeks after 8 days of continuous treatment with sulphanilamide, sulphadimidine, sulphaquinoxaline and pyrimethamine. The results are discussed with reference to physiological data concerning eggwhite and -yolk formation. From this, it is concluded that a withdrawal period of at least 10 days after the disappearance of drug in blood plasma is necessary to avoid residues of drugs in eggs from treated hens. 相似文献
5.
QuEChERS-UPLC-MS/MS快速测定鸡肝中七种磺胺类药物残留 总被引：3，自引：1，他引：2
建立了一种通过QuEChERS方法和超高效液相色谱-串联质谱法快速测定鸡肝中七种磺胺类药物残留量的方法。样品以磺胺二甲氧嘧啶-D6为内标,经DisQuE萃取管提取,DisQuE净化管净化,浓缩后经超高效液相色谱分离,串联质谱测定。结果表明在12.5～125 ng/mL范围内各磺胺类药物均呈良好的线性关系,高中低浓度回收率在70%～115%,精密度小于15%。该方法快速、简便,适于鸡肝中七种磺胺类药物的批量测定。 相似文献
6.
本研究旨在建立同步测定多种磺胺类药物残留的高效液相色谱—紫外法。通过对磺胺嘧啶(SD)、磺胺醋酰(SA)、磺胺喹噁啉(SQ)、磺胺氯丙嗪(SUL)、磺胺间甲氧嘧啶(SMM)、磺胺对甲氧嘧啶(SMD)、磺胺二甲氧嘧啶(SDM')、磺胺异噁唑(SIZ)、磺胺噻唑(ST)、磺胺噻唑钠(ST-Na)、酞磺胺噻唑(PST)、磺胺甲噁唑(SMZ)、琥珀酰磺胺噻唑(SST)等13种磺胺类药物进行紫外波长扫描分析,选择色谱检测的波长为270 nm。由于磺胺类药物的酸碱度不同及结构差异,在经过多种组合比较后,选择乙腈和乙酸水溶液作为流动相进行梯度洗脱,建立的条件可将这些药物分开,13种药物可以分离得到10个色谱峰,ST-Na、PST和ST 3种成分重叠,SDM'和SMZ重叠。用乙腈—氯仿作样品提取并抽提,杂质干扰较少,回收率80%以上,分析用时相对较短。 相似文献
7.
氨苯枫——联磺甲氧苄啶对实验猪卡氏肺孢子虫肺炎的疗效试验 总被引：1，自引：0，他引：1
为判断氨苯枫－联磺甲氧苄啶对人工诱发实验猪卜氏肺孢子虫肺炎的确切疗效。进行了本次试验。将人工诱发卜氏肺孢子虫肺炎成功的１１头实验猪中的１０头接受氨苯枫－联磺甲氧苄啶的治疗,１头为对照。每天治疗猪每次投服氨苯枫２片,联磺甲氧苄啶２片,每天２次,连服１０天。结果实验猪于治疗后５天症状有所缓解,第１０天恢复健康;对照猪症状进一步恶化,于第３天死亡。结果说明此药物组合对卜氏肺孢子虫肺炎有较好的疗效。 相似文献
8.
实验猪卡氏肺孢子虫肺炎模型的建立及药物治疗试验 总被引：3，自引：0，他引：3
在住家及野外诱捕到4只小家鼠、8只黄胸鼠和5只褐家鼠，经皮下注射醋酸可的松10周，建立了鼠类卡氏肺孢子虫(Pneumocystiscarinii,PC)肺炎模型。取模型鼠肺脏制成鼠PC包囊接种物，给实验Ⅰ组8头猪经气管接种3.2×105个PC包囊，且接种前5d至接种后42d肌注醋酸可的松。给实验Ⅱ组8头猪经气管接种6.4×105个PC包囊。接种后，实验Ⅰ组猪均出现严重的临床症状，病理变化呈典型的PC肺炎；实验Ⅱ组猪均为亚临床症状。对实验Ⅱ组猪再注射醋酸可的松后，出现了类似于实验Ⅰ组猪的严重临床症状和病理变化。由此表明，实验猪免疫力低下时，接种外源性PC可导致典型的PC肺炎；健康实验猪接种外源性PC，则呈隐性感染，经免疫抑制剂处理后可激活病原体，导致PC肺炎。用氨苯砜-联磺甲氧苄啶对PC肺炎猪进行治疗试验，取得了较好的效果。 相似文献
9.
F.J.H. Pastoor R. Opitz A.Th. Van ‘t Klooster A.C. Beynen 《The Veterinary quarterly》2013,33(3):157-160
Summary In a 4×4‐vvk cross‐over study, eight adult cats were given four moist diets containing identical amounts of calcium (13.9 mmol/MJ) but with different ratios of calcium carbonate to calcium chloride, the calcium salts providing half of the total dietary calcium. Increasing amounts of calcium chloride were substituted for equimolar amounts of calcium carbonate. Higher intakes of calcium chloride caused significantly lower pH values in postprandial and 24‐h urine samples. The urinary excretion of ammonium and titratable acid rose with increasing calcium chloride intake. The urinary concentrations of calcium and magnesium were not affected by the type of calcium salt, but the urinary excretion and concentration of phosphorus were significantly depressed when the amount of calcium chloride in the diet was increased. The results are discussed in the context of dietary prevention of and therapy for struvite urolithiasis in cats. 相似文献
10.
The renal excretion of N4-acetyl sulphanilamide and N4-acetyl sulphadimidine was studied in 19 experiments with 6 goats during continuous intravenous administration of the 2 sulphonamide derivatives. Deacetylation of both compounds takes place to a small extent only. Further it is shown that both sulphonamide derivatives are bound to plasma proteins to a greater extent than sulphanilamide and sulphadimidine. The excretion of the N4-acetylated sulphonamides is compared with the renal excretion of creatinine. The non-protein-bound fraction of the 2 N4-acetylated sulphonamides is excreted by filtration and active tubular secretion. The renal clearances of the acetyl derivatives are higher than those of the parent compounds. 相似文献