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Goodman LA Jarrett CL Krunkosky TM Budsberg SC Northrup NC Saba CF LeRoy BE 《Veterinary and comparative oncology》2011,9(2):149-157
5-Lipoxygenase (5-LO) is overexpressed in human prostate carcinomas (PCs), and its inhibition decreases proliferation and induces apoptosis in prostate cancer cell lines. We hypothesized that 5-LO would be overexpressed in canine PC compared with benign prostate tissue and may be important in the pathogenesis of the disease. Immunoblot analysis of canine PC and benign prostatic hyperplasia (BPH) tissues demonstrated 5-LO expression in both. 5-LO immunohistochemical staining was not significantly different within the stromal or epithelial components of canine primary PC, BPH or suppurative prostatitis, suggesting that differential expression of this enzyme does not occur in these conditions. The percentage of tumour cells expressing 5-LO was significantly lower in metastatic PC lesions compared with primary PC (P < 0.0001). This decreased expression may indicate down-regulation or altered expression of the enzyme with progression of canine PC to a metastatic phenotype. 相似文献
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目的 探讨慢性前列腺炎伴抑郁症的中医证候分布特点。方法 选取符合病例诊断标准的110例患者进行临床证候调查,根据其临床表现,结合中医证候诊断标准,辨证分析确定其证型;将数据进行统计学处理,分析研究对象各中医证型、证候要素分布的特点。结果 110例患者共计12种证候,包含病位类证素6个,病性类证素11个。实性证候要素中以肝郁、气滞为基本要素,虚性证候要素中以肾虚、脾虚为主,各证候要素按出现频率高低依次为:肝郁 >气滞 >湿热 >肾虚 >痰湿 >脾虚 >血瘀 >心虚 >气虚 >阴虚 >阳虚。结论 慢性前列腺炎伴抑郁症患者中医证候分布具有一定特征性,早期多以实证为主,后期为虚实夹杂证,肾虚肝郁、痰湿瘀阻是其基本病机,为指导临床辨证论治提供了一定的理论依据。 相似文献
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AIM: To investigate the distribution and the antimicrobial resistance of the pathogenic bacteria from chronic bacterial prostatitis. METHODS: Prostatic fluid was collected under sterile condition and was inoculated for bacterial culture. Positive results of bacterial culture were identified by VITEK2 Compact. Drug sensitivity test was carried out with K-B method according to the recommendation of Clinical and Laboratory Standards Institute(CLSI). WHONET 5.6 software was used to analyze the results of drug resistance. RESULTS: Bacteria were identified in 121 patients with chronic prostatitis, most of which were Staphylococcus aureus (29 strains, 23.9%), Staphylococcus haemolyticus (23 strains, 19.0%) and Staphylococcus epidermidis (18 strains, 14.9%). There were 93 strains of Gram-positive bacteria (76.8%), and Gram-negative bacteria were 28 strains (23.2%). The results of drug sensitivity test indicated that Staphylococcus aureus , Staphylococcus haemolyticus and Staphylococcus epidermidis were susceptible to vancomycin, teicoplanin and linezolid, while they were resistant to gentamicin, erythromycin, clindamycin, cefoxitin, oxacillin and ciprofloxacin with the resistant rates from 7.1% to 78.4%. Escherichia coli were susceptible to imipenem, meropenem and ertapenem, while they were resistant to cefotaxime, ceftriaxone, ciprofloxacin, tetracycline and trimethoprim-sulfamethoxazole with different resistant rates (14.5%~69.7%). CONCLUSION: The major pathogenic profile of chronic bacterial prostatitis was Staphylococcus aureus , Staphylococcus haemolyticus, Staphylococcus epidermidis and Escherichia coli . Drugs should be appropriately used on chronic bacterial prostatitis patients base on the results of culture and drug sensitivity test. 相似文献
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抗生素电子仿生信息仪直流电导入加按摩治疗慢性前列腺炎 总被引：1，自引：0，他引：1
目的：观察抗生素电子仿生信息仪直流电导入治疗慢性前列腺炎的疗效。方法：对确诊的１４３例患者随机分为：（１）实验组：７６例用抗生素电子仿生信息仪的直流电导入加按摩疗法治疗；（２）对照组：６７例用抗生素口服或注射加按摩疗法治疗；治疗１～３个疗程结束试验统计疗效。结果：实验组和对照组的治愈率分别为６５．８％、４４．８％；总有效率分别为９３．４％、６５．７％（Ｐ分别＜０．０５，０．０１）。结论：抗生素电子仿生信息仪直流电导入加按摩疗法治疗慢性前列腺炎的疗效好，无任何副作用和不适，操作简便，经济和易为患者所接受 相似文献
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目的观察加减知柏地黄汤对合并不育症的Ⅳ型前列腺炎细胞因子的影响。方法将200例合并不育症的Ⅳ型前列腺炎患者随机分为治疗组(加减知柏地黄汤组)及对照组(前列康片组)各100例,另选30例正常健康男性作为细胞因子基础参考值。两组均治疗3个月,观察治疗后前列腺液(EPS)中白细胞(WBC)计数及白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、白介素-10(IL-10)水平的变化。结果治疗前两组EPS-WBC计数及IL-1β、TNF-α、IL-8、IL-10水平均偏离正常(P<0.05),治疗后两组均能降低EPS-WBC计数及IL-1β、TNF-α、IL-8水平(P<0.05),提高IL-10水平(P<0.05),且治疗组能恢复IL-1β、TNF-α至正常水平,而对照组不能恢复至正常水平。结论Ⅳ型前列腺炎发病与细胞因子失调有关,加减知柏地黄汤能有效降低EPS-WBC计数及调整细胞因子水平。 相似文献
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目的 探讨大黄素、虎杖苷、乳香挥发油配伍对非肥胖性糖尿（non-obese diabetic,NOD）小鼠慢性非细菌性前列腺炎发挥治疗作用的最佳配比。方法 正常雄性NOD小鼠220只,按照L8（27）正交表随机分为8组,另设立阳性对照组、模型组、空白对照组,共11组,每组20只。按组别给予相应干预,酶联免疫吸附法（enzyme-labeled immunosorbent assay,ELISA）检测NOD小鼠前列腺组织匀浆中肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、白介素-1β（interleukin-1β,IL-1β）、白介素-6（interleukin-6,IL-6）、白介素-10（interleukin-10,IL-10）含量的变化,并结合苏木素-伊红（haematoxylin-eosin,HE）染色法评价前列腺组织病理改变程度,明确大黄素、虎杖苷、乳香挥发油的最佳配比与量效关系。结果 正交实验极差结果显示各因素影响强弱依次为虎杖苷 > 大黄素 > 乳香挥发油,方差分析结果发现虎杖苷、大黄素、乳香挥发油对疗效的影响具有统计学意义（P<0.01,P<0.05）。大黄素、虎杖苷、乳香挥发油的最佳配比为大黄素0.1 g/kg、虎杖苷0.4 g/kg、乳香挥发油0.4 g/kg。结论 大黄素、虎杖苷、乳香挥发油的最优比例配伍具有减轻慢性非细菌性前列腺炎动物模型炎症的疗效,乳香挥发油与虎杖苷之间具有协同作用。 相似文献