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1.
鹅副粘病毒的组织嗜性   总被引:2,自引:0,他引:2  
用单克隆抗体介导的免疫过氧化物酶(MC-IP)技术,对21只鹅副粘病毒病鹅体内的病毒抗原进行定位,结合组织病理学观察结果,探讨了鹅副粘病毒的组织嗜性。结果显示,除脑和心脏未检测到病毒外,在气管、肺、食道、肝脏、腺胃、胰腺、肠、哈氏腺、胸腺、脾脏、法氏囊、肾脏等器官都能检测到病毒,病毒抗原定位于上述器官的各种上皮细胞,淋巴细胞、网状细胞和巨噬细胞的胞浆内,其中以胃肠粘膜上皮细胞和法氏囊、胸腺、脾脏的淋巴细胞和网状细胞内检出率高,阳性反应强。这些结果提示,鹅副粘病毒是一种泛嗜性病毒,胃肠粘膜上皮和淋巴组织是其主要侵嗜部位。  相似文献   

2.
鸡腺胃炎是一种以腺胃炎性肿大,胸腺、法氏囊萎缩为主要特征的新传染病,我地区父母代种鸡和商品代肉鸡及产蛋鸡均频繁发生,并且呈逐年递增的趋势。1病原分析目前,该病病原还没明确说法。人们已在腺胃病变组织中观察及分离到多种病毒,有冠状病毒、呼肠孤病毒、禽网状内皮增生症病毒、真菌毒素、肿瘤诱生病毒、多瘤病毒、腺病毒、双RNA病毒等,细菌及饲料原料因素也可引发。我国有人从江苏省病  相似文献   

3.
传染性腺胃炎病原学研究进展   总被引:4,自引:0,他引:4  
自1994年以来,我国十多个省市先后流行了一种以腺胃肿胀,腺胃乳头溃疡为特征的传染病。关于本病的病原众说纷纭,但大多数学者认为是由冠状病毒引起的,作者结合实验室工作,并综述国内外在有关类似症候的传染病后,认为:本病的主要病原应当是网状内皮增生症病毒,但冠状病毒,呼肠孤病毒也在本病的发生中起到重要的协同作用。根据本病的共同性的症状,将该病定名为传染性腺胃炎。  相似文献   

4.
鸡传染性腺胃病的研究进展   总被引:1,自引:0,他引:1  
1995年以来 ,江苏、山东等地鸡群相继发生了一种以腺胃肿大、腺胃乳头溃疡为特征的传染病 ,习惯称为“鸡传染性腺胃病”,临床上也经常有类似病例。为了在生产实践中能给予正确的诊断和防治 ,现就有关资料综述如下。1 病 原该病病原 ,至今仍众说纷纭 ,具体有几种观点 :腺胃型传染性支气管炎病毒、呼肠弧病毒 (Reovirus,REO)、网状内皮组织增生病病毒 (Reticuloendotheliosis,REV)等。1 .1 腺胃型传染性支气管炎病毒 (即冠状病毒 ) 王永坤 (1 996 )、王玉东 (1 997)等先后从鸡传染性腺胃病的病料中分离到了冠状病毒 ,认为该病原是 IB…  相似文献   

5.
为诊断2019年11月山东某规模化养鸡场商品肉鸡暴发腺胃炎的病因,本试验对病鸡进行临床、大体病变、组织病理和血涂片观察以及病原学检测。结果显示,发病鸡主要表现为生长停滞(矮小),精神沉郁,消瘦,消化不良等;大体病变表现为胸肌苍白,腺胃肿大,腺胃乳头消失,脾脏和法氏囊萎缩;组织病变表现为腺胃炎性细胞浸润,腺管上皮细胞增生,腺胃和十二指肠均有淋巴细胞浸润,可见核分裂象;血涂片中发现大量幼稚红细胞和异形性红细胞,并且异嗜性粒细胞增多;血琼脂培养基长出大小均匀一致的灰白色单一菌落;聚合酶链式反应(PCR)检测显示为大肠杆菌(E.coli);病毒PCR检测显示为网状内皮组织增生病病毒(REV)、鸡贫血病毒(CAV)。最终该病例诊断为REV、CAV、E.coli混合感染引起肉鸡腺胃炎。  相似文献   

6.
<正>传染性腺胃炎是一种以鸡群高度精神沉郁、生长迟缓、苍白消瘦、粪便中有未消化或消化不良饲料,剖检以腺胃肿大呈球状、腺胃乳头充血、出血、溃疡,免疫器官萎缩为特征的慢性疾病。1病原关于本病的病原众说纷云,分别有不同学者在发病鸡只中先后分离到鸡冠状病毒、呼肠孤病毒、禽网状内皮组织增生症病  相似文献   

7.
应用荧光PCR试剂盒对临床表现为消瘦和腺胃肿大为特征的患鸡病料进行鸡传染性支气管炎病毒(IBV)、禽网状内皮组织增殖病病毒(REV)和鸡马立克氏病病毒(MDV)核酸检测。结果显示:鸡传染性支气管炎病毒荧光RT-PCR检测为阳性,禽网状内皮组织增殖病病毒荧光RT-PCR检测为阴性,鸡马立克氏病病毒荧光PCR检测为阴性。结合患鸡精神沉郁,极度消瘦,腺胃肿大如球状等的临床表现,综合分析表明该患鸡发病主要病因为感染鸡腺胃型传染性支气管炎病毒。  相似文献   

8.
正在禽病临床诊治过程中,时常遇到肝脏不太肿大,但肝脏上有大小不一的灰白色肿瘤结节。病理解剖病变特点是肝脏、心脏、脾脏、卵巢、肾脏、肠道等内脏器官有淋巴瘤,胸腺和法氏囊萎缩,腺胃有时异常肿大。这种病称之为网状内皮增生症。鸡网状内皮增生症是由网状内皮组织增生症病毒引起的一种肿瘤性传染病,1966年有专家证实本病毒与白血病毒为同属病毒,但有若干的差异,而命名为网状内皮增生症病毒。感染后病鸡表现为  相似文献   

9.
近几年一种以鸡生长不良、消瘦、整齐度差、腺胃肿大呈乳白色球状、腺胃黏膜溃疡、脱落、腺一肌胃交界处糜烂为主要特征的鸡病给养鸡业造成了重大的经济损失。因为该病的临床症状、病理变化表现不尽相同,有人分离出了类细小病毒粒子、呼肠病毒、肿瘤诱生病毒、禽网状内皮增生症病毒、冠状病毒、多瘤病毒、萼状病毒、肠病毒、腺病毒、新城疫病毒、双RNA病毒和细菌等等。  相似文献   

10.
鸡传染性腺胃炎是一种由多种原因引起的鸡腺胃综合征,主要以鸡的生长缓慢或阻滞、腺胃肿大充血、腺胃乳头出血、溃疡甚至糜烂为特征的传染性疾病。鸡传染性腺胃炎的病原较复杂,可能主要有禽网状内皮组织增殖病病毒、冠状病毒、鸡痘病毒及霉菌毒素等构成。一般认为该病的发生由病毒、霉菌及细菌等多种因素协同作用。由于病因尚无定论,加之该病防制困难,给养禽业造成了重大的经济损失。文章就鸡传染性腺胃炎几个主要的发病原因进行分析和叙述。  相似文献   

11.
试验选用96头平均体重14.82 kg左右的杜×长×大断奶仔猪,随机分成4组,每组3栏,每栏8头(公母各半)。对照组饲喂基础日粮,试验1、2、3组分别添加1%80目白术、0.2%白术多糖和1%微米白术。试验期30 d。结果表明:在生长性能方面,与对照组相比,1%微米白术添加组可显著提高日增重(P0.05)、降低饲料增重比和腹泻率,而且效果优于1%80目白术组和0.2%白术多糖组,在肠道形态和肠道微生态区系方面,与对照组相比,日粮添加1%80目白术、0.2%白术多糖、1%微米白术均可不同程度的提高十二指肠和空肠的绒毛高度,加深十二指肠和空肠的隐窝深度,并且增加肠道微生态区系的多样性,其中以1%微米白术添加组的效果最佳。  相似文献   

12.
Sissay, M.M., Uggla, A. and Waller, P.J., XXXX. Prevalence and seasonal incidence of nematode parasites and fluke infections of sheep and goats in eastern Ethiopia. Tropical Animal Health and Production, XXXX. A 2-year abattoir survey was carried out to determine the prevalence, abundance and seasonal incidence of gastro-intestinal (GI) nematodes and trematodes (flukes) of sheep and goats in the semi-arid zone of eastern Ethiopia. During May 2003 to April 2005, viscera including liver, lungs and GI tracts were collected from 655 sheep and 632 goats slaughtered at 4 abattoirs located in the towns of Haramaya, Harar, Dire Dawa and Jijiga in eastern Ethiopia. All animals were raised in the farming areas located within the community boundaries for each town. Collected materials were transported within 24 h to the parasitology laboratory of Haramaya University for immediate processing. Thirteen species belonging to 9 genera of GI nematodes (Haemonchus contortus, Trichostrongylus axei, T. colubriformis, T. vitrinus, Nematodirus filicollis, N. spathiger, Oesophagostomum columbianum, O. venulosum, Strongyloides papillosus, Bunostomum trigonocephalum, Trichuris ovis, Cooperia curticei and Chabertia ovina), and 4 species belonging to 3 genera of trematodes (Fasciola hepatica, F. gigantica, Paramphistomum {Calicohoron} microbothrium and Dicrocoelium dendriticum) were recorded in both sheep and goats. All animals in this investigation were infected with multiple species to varying degrees. The mean burdens of adult nematodes were generally moderate in both sheep and goats and showed patterns of seasonal abundance that corresponded with the bi-modal annual rainfall pattern, with highest burdens around the middle of the rainy season. In both sheep and goats there were significant differences in the mean worm burdens and abundance of the different nematode species between the four geographic locations, with worm burdens in the Haramaya and Harar areas greater than those observed in the Dire Dawa and Jijiga locations. Similar seasonal variations were also observed in the prevalence of flukes. But there were no significant differences in the prevalence of each fluke species between the four locations. Overall, the results showed that Haemonchus, Trichostrongylus, Nematodirus, Oesophagostomum, Fasciola and Paramphistomum species were the most abundant helminth parasites of sheep and goats in eastern Ethiopia.  相似文献   

13.
14.
1-(2-Chloroethyl)3-cyclohexyl-1-nitrosourea (CCNU) is an alkylating agent in the nitrosourea subclass. A prospective evaluation of CCNU was done to determine the maximally tolerated dosage of CCNU in tumor-bearing cats. Response data were obtained when available. Twenty-five cats were treated with CCNU at a dosage of 50-60 mg/m3 body surface area. Complete hematologic data were available for 13 cats. Neutropenia was the acute dose-limiting toxicity. The median neutrophil count at the nadir was 1,000 cells/microL (mean, 2,433 cells/microL; range, 0-9,694 cells/microL). The time of neutrophil nadir was variable, occurring 7-28 days after treatment, and counts sometimes did not return to normal for up to 14 days after the nadir. Based on these findings, a 6-week dosing interval and weekly hematologic monitoring after the 1st treatment with CCNU are recommended. The nadir of the platelet count may occur 14-21 days after treatment. The median platelet count at the nadir was 43,500 cells/microL. No gastrointestinal, renal, or hepatic toxicities were observed after a single CCNU treatment, and additional studies to evaluate the potential for cumulative toxicity should be performed. Five cats with lymphoma and 1 cat with mast cell tumor had measurable responses to CCNU. Phase II studies to evaluate antitumor activity should be completed with a dosing regimen of 50-60 mg/m3 every 6 weeks.  相似文献   

15.
Our particular attention in this article was given to natural mediators for macrophages isolated from the sites of tissue injury. A number of chemotactic factors, which may satisfy many criteria making them acceptable as inflammatory leucocyte chemotactic factors, has been separated. Among them, our laboratory has isolated three macrophage (monocyte) chemotactic factors (MCF-a, -b and -c). Their purification, characterization and functional specificity are discussed.  相似文献   

16.
Human and equine athletes are reported to have a high prevalence of gastric disease, and anecdotal evidence suggests a similar phenomenon applies to racing sled dogs. To investigate the prevalence of gastric disease in racing sled dogs, we conducted 2 gastroscopy studies on dogs competing in the annual Iditarod Sled Dog Race. A pilot study of dogs that were either dropped from the 2000 Iditarod Sled Dog Race because of illness or that finished the race indicated that, approximately 5 days after competing, 10 of 28 dogs (35%) had endoscopic evidence of gastric ulceration, erosion, or hemorrhage. The next year, an endoscopic study of 73 dogs participating in the 2001 Iditarod race was performed in order to evaluate a larger population of dogs. Data from 70 of these dogs could be used; 34 (48.5%) had ulceration, erosion, gastric hemorrhage, or some combination of these findings. When this group of 70 dogs was compared retrospectively to a control group of 87 dogs presented to the Texas A&M University (TAMU) Veterinary Medical Teaching Hospital, the Iditarod sled dogs had a significantly higher prevalence (P = .049) of gastric lesions. These findings suggest that, similar to athletes of other species, elite canine athletes have an increased prevalence of gastric disease compared to the canine population at large.  相似文献   

17.
Continuous rate infusion (CRI) of furosemide in humans is considered superior to intermittent administration (IA). This study examined whether furosemide CRI, compared with IA, would increase diuretic efficacy with decreased fluid and electrolyte fluctuations and activation of the renin-angiotensin-aldosterone system (RAAS) in the horse. Five mares were used in a crossover-design study. During a 24-hour period, each horse received a total of 3 mg/kg furosemide by either CRI (0.12 mg/kg/h preceded by a loading dose of 0.12 mg/kg IV) or IA (1 mg/kg IV q8h). There was not a statistically significant difference in urine volume over 24 hours between methods; however, urine volume was significantly greater after CRI compared with IA during the first 8 hours ([median 25th percentile, 75th percentile]: 9.6 L [8.9, 14.4] for CRI versus 5.9 L [5.3, 6.0] for IA). CRI produced a more uniform urine flow, decreased fluctuations in plasma volume, and suppressed renal concentrating ability throughout the infusion period. Potassium, Ca, and Cl excretion was greater during CRI than IA (1,133 mmol [1.110, 1,229] versus 764 mmol [709, 904], 102.7 mmol [96.0, 117.2] versus 73.3 mmol [65.0, 73.5], and 1,776 mmol [1,657, 2.378] versus 1,596 mmol [1,457, 1,767], respectively). Elimination half-lives of furosemide were 1.35 and 0.47 hours for CRI and IA, respectively. The area under the excretion rate curve was 1,285.7 and 184.2 mL x mg/mL for CRI and IA, respectively. Furosemide CRI (0.12 mg/kg/h) for 8 hours, preceded by a loading dose (0.12 mg/kg), is recommended when profound diuresis is needed acutely in horses.  相似文献   

18.
Genetic variations in chromosome Y are enabling researchers to identify paternal lineages, which are informative for introgressions and migrations. In this study, the male‐specific region markers, sex‐determining region‐Y (SRY), amelogenin (AMELY) and zinc finger (ZFY) were analysed in seven Turkish native goat breeds, Angora, Kilis, Hair, Honaml?, Norduz, Gürcü and Abaza. A SNP in the ZFY gene defined a new haplotype Y2C. All domestic haplogroups originate from Capra aegagrus, while the finding of Y1A, Y1B, Y2A and Y2C in 32, 4, 126 and 2 Turkish domestic goats, respectively, appears to indicate a predomestic origin of the major haplotypes. The occurrence of four haplotypes in the Hair goat and, in contrast, a frequency of 96% of Y1A in the Kilis breed illustrate that Y‐chromosomal variants have a more breed‐dependent distribution than mitochondrial or autosomal DNA. This probably reflects male founder effects, but a role in adaptation cannot be excluded.  相似文献   

19.
The objective of this report was to characterize 20-year changes in proportion of calcium oxalate (CaOx) calculi and struvite calculi in dogs, and associations with breed, age, and sex. In this retrospective study, results of analysis of urinary calculi from dogs were reviewed for specimens received between July 1, 1981, and December 31, 2001. Breed, sex, age, year of submission of the specimen, and mineral type(s) were analyzed statistically. CaOx or Struvite or both were contained in 18,966 of 20,884 (91%) specimens. For both sexes, a 20-year statistically significant increase was observed in the proportion of calculus specimens that contained CaOx. The increase in this proportion was greater in females (1% to 31%) than in males (18% to 82%). From 1998 to 2001, when proportions may have plateaued, the odds of specimens containing CaOx were markedly higher in 18 breeds, markedly lower in 5 breeds, and not significantly different in 13 breeds compared with crossbreds. For both sexes, a 20-year statistically significant decrease was observed in the proportion of calculus specimens that contained struvite. This decrease in proportion was greater for males (79-16%) than for females (97-68%). From 1998 to 2001, when proportions plateaued, the odds of calculi containing struvite were markedly lower in 20 breeds, markedly higher in 1 breed, and not significantly different in 15 breeds when compared with crossbreds. Breed, age, and sex were associated statistically with CaOx or struvite urolithiasis. In conclusion, there appears to have been a long-term increase in the proportion of specimens of canine urinary calculi that contain CaOx as well as a long-term decrease in the proportion of specimens of calculi that contain struvite for both male and female dogs. The rate of change appeared to begin leveling off in the period 1998 to 2001. The recent proportion of dogs with either CaOx- or struvite-associated urolithiasis may depend on breed, age, and sex, and on interactions among these 3 factors.  相似文献   

20.
<正>1.INTRODUCTION Ensuring transportation network security is one Of the most daunting challenges confronting homeland security agencies today.Significant research has been dedicated.To model and analyze the vulnerability of transportation systems,while notably fewer studies propose specific strategies for deploying defensive technologies to safeguard these systems.  相似文献   

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