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鸡传染性贫血病的流行病学与诊断 总被引：1，自引：0，他引：1
鸡传染性贫血病(CIA)是由鸡传染性贫血病毒(CIAV)引起的,主要侵害雏鸡并导致再生障碍性贫血和免疫抑制为主要特征的一种传染病.CIAV感染鸡群可引起机体免疫机能障碍,造成免疫抑制,使鸡群对其他病原微生物的易感性增高和对疫苗的免疫应答能力下降,从而发生继发感染和疫苗的免疫失败,引起严重经济损失. 相似文献
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鸡传染性贫血病的防制 总被引：1，自引：0，他引：1
鸡传染性贫血病(CIA)是由鸡传染性贫血病毒(CIAV)引起的主要以雏鸡再生障碍性贫血和全身性淋巴组织萎缩为主要特征的免疫抑制病.该病在临床上主要导致雏鸡的生长发育不良、渗出性皮炎和死亡,又称为蓝翅病、出血性综合征和贫血性皮炎综合征等,其引起感染鸡的免疫抑制常常导致其他病原微生物的继发感染,常常给养鸡业造成严重的经济损失. 相似文献
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《山东畜牧兽医》2016,(12)
正鸡传染性贫血病(CIA)是由鸡传染性贫血病毒(CIAV)引起的一种使能使感染鸡再生障碍性贫血、淋巴组织萎缩、出血的病毒性传染病。鸡传染性贫血病(CIA)主要发生于2~4周龄的雏鸡,导致雏鸡贫血和成鸡的免疫抑制。目前,鸡传染性贫血病对养鸡业的危害不断上升,已引起世界各个养禽国家的广泛关注,如何有效的进行防治成为一大热点,本文就近些年鸡传染性贫血病(CIA)的研究进展及防治措施做一综述。鸡传染性贫血病是由圆环病毒科(Circoviridae)陀螺病毒(Gyrovirus)属的鸡传染性贫血病毒(Chicken infectious anemia virus,CIAV)引起的,临床上以贫血、骨髓黄染、全身淋巴组织萎缩和免疫机能损害为主要特征。1979年 相似文献
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鸡传染性贫血病（CIA）是由鸡传染性贫血病毒（CIAV）引起的,主要侵害雏鸡并导致再生障碍性贫血和免疫抑制为主要特征的一种传染病。CIAV感染鸡群可引起机体免疫机能障碍,造成免疫抑制,使鸡群对其他病原微生物的易感性增高和对疫苗的免疫应答能力下降,从而发生继发感染和疫苗的免疫失败,引起严重经济损失。 相似文献
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鸡传染性贫血病（CIA）是由鸡传染性贫血病毒（CIAV）引起的主要以雏鸡再生障碍性贫血和全身性淋巴组织萎缩为主要特征的免疫抑制病。该病在临床上主要导致雏鸡的生长发育不良、渗出性皮炎和死亡，又称为蓝翅病、出血性综合征和贫血性皮炎综合征等，其引起感染鸡的免疫抑制常常导致其他病原微生物的继发感染，常常给养鸡业造成严重的经济损失。 相似文献
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鸡传染性贫血病毒是鸡传染性贫血病的病原体,能引起雏鸡贫血、淋巴组织萎缩、出血及免疫抑制,是导致许多疫苗免疫失败及雏鸡死亡的主要原因之一。该病毒在世界范围内广泛存在,是养鸡业潜在的巨大威胁。近年来的研究表明,鸡传染性贫血病毒主要是通过其编码的凋亡素诱导雏鸡胸腺和骨髓中的造血祖细胞凋亡而致病的,而凋亡素诱导细胞凋亡的能力与其在细胞中的核定位及半胱氨酸蛋白酶(caspase)等因素密切有关。文章就鸡传染性贫血病毒生物学特征、诱导细胞凋亡的现象及机制的研究进行了综述。 相似文献
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应用免疫SPA菌体不法和间接ELISE法对鸡传染性贫血病（CIA）疫苗免疫母鸡后，其子代雏鸡外周血液T细胞数量和血清IgG,IgM,IgA含量进行了动态研究。结果发现：CIA疫苗免疫母鸡后，其子代雏鸡外周血液T细胞数量和IgG,IgM,IgA含量均不同和蔼地高于未免疫的相对照雏鸡，表明CIA疫苗免疫母后，其子代雏鸡全身的体液上述各项指标均明显低于疫苗免疫的子代雏鸡，这与CIAV强毒攻击子代雏鸡后，未免疫的子代雏鸡外周血液上述各项指标均明显低于疫苗免疫的子代雏鸡，这与CIAV强毒感染雏鸡后，其免疫器官组织，尤其是胸腺严重损害，淋巴细胞变性坏死子等密切相关，是导致感染鸡免疫功能低下的基础。 相似文献
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鸡贫血病-法氏囊病联合免疫母鸡后子代雏鸡外周血液T细胞数量及免疫球蛋白含量变化 总被引：1，自引：1，他引：0
应用免疫SRA菌体花环法和间接ELISE法对鸡传染性贫血病 (CIA) -传染性法氏囊病 (IBD)联合免疫母鸡后 ,其子代雏鸡外周血液T细胞数量和免疫球蛋白IgG、IgM、IgA含量变化进行了动态研究。结果发现 ,CM -IBD联合免疫母鸡后 ,其子代雏鸡外周血液T细胞数量和IgG、IgM、IgA含量均不同程度地高于未免疫的相应对照雏鸡 ,表明CIA-IBD联合免疫母鸡后 ,其子代雏鸡外周血液体液免疫和细胞免疫功能明显增强。而CIAV、IBDY强毒攻击后 ,未免疫的子代雏鸡 ,其外周血液的上述指标均明显低于疫苗免疫的子代雏鸡 ,表明未免疫的子代雏鸡外周血液的免疫机能降低 ,这与未免疫雏鸡缺乏特异性抗体 ,强毒攻击后 ,雏鸡免疫器官组织广泛损害 ,淋巴细胞变性坏死等有关 相似文献
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应用免疫SPA菌体花环法、MTT法和间接ELISA法对鸡传染性贫血病(CIA)-传染性法氏囊病(IBD)联合免疫种鸡后,其子代雏鸡外周血液T细胞数量和增殖功能以及免疫球蛋白IgG、IgM、IgA含量变化进行了动态研究。结果发现,CIA-IBD联合免疫种鸡后,其子代雏鸡外周血液T细胞数量和IgG、IgM、IgA含量均不同程度地高于未免疫的相应对照雏鸡,表明CIA-IBD联合免疫种鸡后,其子代雏鸡外周血液体液免疫和细胞免疫功能明显增强。而CIAV、IBDV强毒攻击后,未免疫的子代雏鸡,其外周血液的上述指标均明显低于疫苗免疫的子代雏鸡,表明未免疫的子代雏鸡外周血液的免疫机能降低,这与未免疫雏鸡缺乏特异性抗体,强毒攻击后,雏鸡免疫器官组织广泛损害,淋巴细胞变性坏死等有关。 相似文献
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鸡传染性贫血疫苗免疫母鸡后子代雏鸡的免疫学变化 总被引：1，自引：0，他引：1
应用免疫学新技术对鸡传染性贫血（CIA）疫苗免疫母鸡后，其子代雏鸡外周血液和免疫器官组织及局部体液的免疫学变化进行了动态研究。结果表明：CIA疫苗免疫母鸡后，其子代雏鸡外周血液T、B细胞数量和IgG、IgM、IgA含量及免疫器官组织的T细胞和IgG、IgM、IgA抗体生成细胞以及泪液、气管液、胆汁、肠液的IgA、IgM、IgG含量均不同程度地高于未免疫的相应对照雏鸡，表明CIA疫苗免疫母鸡后，其子代雏鸡全身的体液免疫和细胞免疫功能明显增强。而CIAV强毒攻击后，未免疫的子代雏鸡，其外周血液和免疫器官组织及局部体液的上述各项指标均明显低于疫苗免疫的子代雏鸡。 相似文献
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A case-control study was performed to determine the significance of chicken infectious anemia virus (CIAV) as a risk factor associated with secondary disease in commercial broilers and to identify the significance of production losses associated with CIAV. The study also examined the relationship between bursal and thymic atrophy and the presence of CIAV. Cases were defined as submissions to the Alabama Veterinary Diagnostic Laboratories with a history of clinical disease and with a diagnosis of coccidiosis, gangrenous dermatitis, or respiratory disease. Controls were selected from submissions with neither a history of disease nor evidence of disease on necropsy. CIAV was detected in fresh tissues by polymerase chain reaction. Both thymic atrophy and the detection of CIAV were significantly associated with a disease case (P < 0.05). Bursal atrophy was a significant risk factor associated with the detection of CIAV in a submission (P < 0.05). Whereas CIAV was associated with disease cases that showed production losses in both percentage of livability and percentage of condemnations (P < 0.05), detection of CIAV alone was not associated with detectable losses in production or flock performance. 相似文献
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Davidson I Kedem M Borochovitz H Kass N Ayali G Hamzani E Perelman B Smith B Perk S 《Avian diseases》2004,48(1):108-118
The impact of chicken infectious anemia virus (CIAV) infection on commercial chicken flocks in Israel was examined by analyzing flocks with or without typical CIAV signs, signs of other diseases, or apparently healthy flocks. In 23 flocks (broilers and layers) of ages up to 8 wk, typical signs of CIAV infection (stunting, gangrenous dermatitis, and secondary bacterial infections) were recorded. When permitted by flock owners, in several cases among these 23 flocks the morbidity, mortality, and performance parameters were recorded; the presence of CIAV was detected by polymerase chain reaction (PCR); and the antibody status of parents and broilers was measured. In addition, total mortality, number of birds sold, total kilograms of meat sold, density (kg/m2), mean age at slaughter, daily growth rate in grams, total kilogram of food consumed, food conversion rate, and the European Index were calculated. We also surveyed flocks affected by other diseases, such as tumors, respiratory diseases, or coccidiosis, and flocks with no apparent clinical signs. The latter flocks were negative by CIAV-PCR, indicating that typical CIAV clinical signs are associated with one-step PCR-CIAV amplification. However, a small amount of CIAV might still be present in these flocks, acting to induce the subclinical effects of CIAV infection. These data indicate a link between the presence of virus sequences and typical CIAV signs and strengthen the concept that CIAV infection has a negative economic impact on the chicken industry. 相似文献
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Chicken infectious anemia virus (CIAV) is a ubiquitous and highly resistant virus of chickens that causes anemia and death in chicks less than 3 wk of age and immunosuppression in chickens older than 3 wk of age. The production of specific-pathogen-free eggs free of CIAV is essential for research and vaccine production. Currently, flocks are screened for CIAV by antibody tests to ensure freedom from CIAV infection. Recent evidence, however, indicates that chickens may carry and vertically transmit CIAV DNA independently of their antibody status. In this study, we tested embryos and eggshell membrane residues by nested polymerase chain reaction (PCR) as a sensitive method of detecting CIAV DNA. CIAV DNA could be detected in the blastodisks and semen obtained from antibody-positive and -negative chickens. Examination of different tissues between 18 and 20 days of incubation indicated that many but not all organs of individual embryos were positive. The lymphoid organs and gonads had the highest incidence of CIAV DNA, which was significantly different (P < 0.05) from the incidence in the liver. Eggshell membrane samples from embryos or newly hatched chicks were an excellent noninvasive source for the detection of CIAV DNA, identifying significantly more positive embryos than did pooled lymphoid organs. The use of dexamethasone injections as a method to improve the detection of carrier birds did not result in an increase of vertical transmission or cause seroconversion in the treated hens. A combination of testing eggshell membrane residues at hatch and periodic testing of blood DNA by nested PCR can be used to identify chickens carrying CIAV DNA and may be used to eradicate carrier birds. 相似文献