Key Factors Affecting Reproductive Success of Thoroughbred Mares and Stallions on a Commercial Stud Farm          下载免费PDF全文

EA Lane  MLJ Bijnen  M Osborne  SJ More  ISF Henderson  P Duffy  MA Crowe 《Reproduction in domestic animals》2016,51(2):181-187

To evaluate factors contributing to fertility of thoroughbred mares, data from 3743 oestrous periods of 2385 mares were collected on a large thoroughbred farm in Ireland. Fourteen stallions (mean age 8.3 years; range 4–15 years) had bred 2385 mares (mean age 9.4 years; range 3–24 years). Maiden mares accounted for 12%, mares with a foal at foot for 64%, and barren, slipped or rested mares for 24% of the total. The mean pregnancy rate per cycle was 67.8% (68.6% in year 1 and 66.9% in year 2). Backward stepwise multivariable logistic regression analysis was utilized to develop two models to evaluate mare factors, including mare age, reproductive status, month of foaling, dystocia, month of cover, foal heat, cycle number, treatments, walk‐in status and stallion factors including stallion identity, stallion age, shuttle status, time elapsed between covers and high stallion usage on the per cycle pregnancy rate and pregnancy loss. Old age (p < 0.001) and cover within 20 days post‐partum (p < 0.003) were associated with lowered pregnancy rates. High mare age (p < 0.05) and barren, slipped or rested reproductive status (p = 0.05) increased the likelihood of pregnancy loss. Uterine inflammation or infection, if appropriately treated, did not affect fertility. Only high usage of stallions (used more than 21 times in previous week) was associated with lowered (p = 0.009) pregnancy rates. However, shuttle stallions were more likely to have increased (p = 0.035) pregnancy survival, perhaps reflecting a bias in stallion selection. In conclusion, mare age exerted the greatest influence on fertility; nonetheless, thoroughbreds can be effectively managed to achieve high reproductive performance in a commercial setting.  相似文献   

The effects of vaccination of Merino ewes with an attenuated Australian bluetongue virus serotype 23 at different stages of gestation   总被引：1，自引：0，他引：1  

M. FLANAGAN  SJ JOHNSON 《Australian veterinary journal》1995,72(12):455-457

SUMMARY A cell culture attenuated Australian bluetongue virus serotype 23 (BLU23) prototype vaccine was assessed for its effects on pregnant Merino sheep. Seventy-six ewes were vaccinated at 5 different stages of gestation, and the failure to lamb at term was as follows: 35 to 43 days of gestation, 20/36 (56%); 57 to 64 days of gestation, 3/10 (30%); 81 to 88 days of gestation, 3/10 (30%); 109 to 116 days of gestation, 0/10 (0%); 130 to 137 days of gestation, 0/10 (0%). Of 30 ewes vaccinated with a cell culture supernatant fluid control between 35 and 43 days of gestation, 6.7% (2/30) failed to lamb at term. Two ewes vaccinated with BLU23 vaccine between 35 and 43 days of gestation had lambs with hydranencephaly. All other lambs born were clinically normal. Three ewes vaccinated with BLU23 aborted. Two of these were vaccinated between 35 and 43 days of gestation, the 3rd between 81 and 88 days of gestation. Five lambs were born with BLU group antibody. Four of these were from ewes vaccinated between 35 and 43 days of gestation, and 2 of these had hydranencephaly. The fifth was from a ewe vaccinated between 57 and 64 days of gestation. The vaccine did not produce disease in adult sheep, but was a potent cause of early foetal death and to a much lesser extent foetal malformation.  相似文献   

Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985-1995)     

Williams LE  Gliatto JM  Dodge RK  Johnson JL  Gamblin RM  Thamm DH  Lana SE  Szymkowski M  Moore AS;Veterinary Cooperative Oncology Group 《Journal of the American Veterinary Medical Association》2003,223(6):825-831

OBJECTIVE: To characterize the signalment, clinical signs, biological behavior, and response to treatment of carcinoma of the apocrine glands of the anal sac in dogs. DESIGN: Retrospective study. ANIMALS: 113 dogs with histologically confirmed carcinoma of the apocrine glands of the anal sac. PROCEDURE: Data on signalment, clinical signs, and staging were reviewed and analyzed along with treatment modality for potential association with survival time. RESULTS: Sex distribution was approximately equal (54% female, 46% male). One hundred four dogs underwent treatment consisting of surgery, radiation therapy, chemotherapy, or multimodal treatment. Median survival for treated dogs was 544 days (range, 0 to 1,873 days). Dogs treated with chemotherapy alone had significantly shorter survival (median, 212 days) than those receiving other treatments (median, 584 days). Dogs not treated with surgery had significantly shorter survival (median, 402 days) than those that underwent surgery as part of their treatment (median, 548 days). Dogs with tumors > or = 10 cm2 had significantly shorter survival (median, 292 days) than dogs with tumors < 10 cm2 (median, 584 days). Hypercalcemia was identified in 27% (n = 29) of dogs, and those dogs had significantly shorter survival (median, 256 days), compared with those that were normocalcemic (median, 584 days). Dogs with pulmonary metastasis had significantly shorter survival (median, 219 days) than dogs without evidence of pulmonary metastasis (median, 548 days). CONCLUSIONS AND CLINICAL RELEVANCE: Unlike most previous reports, this study revealed an approximately equal sex distribution, and results suggest a more favorable prognosis.  相似文献   

Gram-negative Mastitis in Early Lactation May Interfere with Ovarian and Certain Endocrine Functions and Metabolism in Dairy Cows   总被引：1，自引：0，他引：1  

G Huszenicza  S Jánosi  M Kulcsár  P Kóródi  SJ Dieleman  J Bartyik  P Rudas  P Ribiczei-Szabó 《Reproduction in domestic animals》1998,33(3-4):147-153

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The structure and receptor binding properties of the 1918 influenza hemagglutinin   总被引：1，自引：0，他引：1  

Gamblin SJ  Haire LF  Russell RJ  Stevens DJ  Xiao B  Ha Y  Vasisht N  Steinhauer DA  Daniels RS  Elliot A  Wiley DC  Skehel JJ 《Science (New York, N.Y.)》2004,303(5665):1838-1842

The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.  相似文献   

Imaging of intermittency in ripple-wave turbulence     

WB Wright  R Budakian  DJ Pine  SJ Putterman 《Science (New York, N.Y.)》1997,278(5343):1609-1612

The dynamics of a fluid surface filled with high-amplitude ripples were studied with a technique (diffusing light photography) that resolves the height at all locations instantaneously. Even when nonlinearities are strong enough to generate a (Kolmogorov) cascade from long wavelength (where energy is input) to shorter wavelength, the resulting turbulent state contains large coherent spatial structures. The appearance of these structures in a thermal equilibrium state (with the same average energy) would be highly improbable.  相似文献   

A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins   总被引：2，自引：0，他引：2  

Corti D  Voss J  Gamblin SJ  Codoni G  Macagno A  Jarrossay D  Vachieri SG  Pinna D  Minola A  Vanzetta F  Silacci C  Fernandez-Rodriguez BM  Agatic G  Bianchi S  Giacchetto-Sasselli I  Calder L  Sallusto F  Collins P  Haire LF  Temperton N  Langedijk JP  Skehel JJ  Lanzavecchia A 《Science (New York, N.Y.)》2011,333(6044):850-856

The isolation of broadly neutralizing antibodies against influenza A viruses has been a long-sought goal for therapeutic approaches and vaccine design. Using a single-cell culture method for screening large numbers of human plasma cells, we isolated a neutralizing monoclonal antibody that recognized the hemagglutinin (HA) glycoprotein of all 16 subtypes and neutralized both group 1 and group 2 influenza A viruses. Passive transfer of this antibody conferred protection to mice and ferrets. Complexes with HAs from the group 1 H1 and the group 2 H3 subtypes analyzed by x-ray crystallography showed that the antibody bound to a conserved epitope in the F subdomain. This antibody may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency.  相似文献   

Evaluation of a regimen using a progesterone releasing intravaginal device (CIDR) and PMSG as a treatment for post partum anoestrus in dairy cattle     

TF. JUBB  P. BRIGHTLING  J. MALMO†  MT. LARCOMBE  GA. ANDERSON  SJ. HIDES‡ 《Australian veterinary journal》1989,66(10):334-336

Anoestrous dairy cows in seasonally calving herds in the Macalister Irrigation District of Gippsland, Victoria were treated at the start of the mating period with a progesterone releasing intravaginal device (CIDR). The CIDR was inserted for 7 days and 400 IU of PMSG was injected intramuscularly at removal. There was no clinically useful difference among cows receiving the CIDR, a placebo and untreated cows in the interval from treatment to either first oestrus or conception, the conception rate to first service or percent pregnant by the end of mating. Analyses of data from 2-year-old cows, older cattle, cows calved at least 45 days or cows calved at least 55 days and cows treated 3 weeks after the start of mating did not show improved reproductive performance following treatment with the CIDR.  相似文献   

An attempt to prevent acute toxoplasmosis in macropods by vaccination with Hammondia hammondi     

GL REDDACLIFF  SJ PARKER  JP DUBEY  PJ NICHOLLS  AM JOHNSON  DW COOPER 《Australian veterinary journal》1993,70(1):33-35

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Assessment of tetracycline and Babesia culture supernatant as prophylactics for moderating reactions in cattle to live Babesia and Anaplasma vaccines     

WK JORGENSEN  RE BOCK  TG KINGSTON  AJ DE VOS  SJ WALDRON 《Australian veterinary journal》1993,70(1):35-36

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