Mitteilung über Schadmilben im Vorderen Orient     

Saba  F. 《Journal of pest science》1964,37(2):17-19

Zusammenfassung Die wichtigsten Milben von wirtschaftlicher Bedeutung im Libanon, Jordanien und der südlichen Türkei werden aufgeführt. Es handelt sich auf Äpfeln um:Tetranychus urticae, Metatetranychus ulmi, Tetranychus cinnabarinus, Bryobia rubrioculus; aufCitrus sp. um:Phyllocoptruta oleivora, Aceria sheldoni ,Eutetranychus orientalis, Brevipalpus obovatus, T. cinnabarinus: auf Gemüsearten um:Tetranychus urticae, T. cinnabarinus; auf Wein um:Eriophyes vitis; auf Granatäpfeln um:Eriophyes granati.Die Orte und Daten der Befunde werden angegeben.

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Summary The mites of economic importance in the Lebanons, Jordan and South-Turkey are listed with the dates and places in which they were found. On apples were found:Tetranychus urticae, Metatetranychus ulmi, Tetranychus cinnabarinus, Bryobia rubrioculus; onCitrus sp.: Phyllocoptruta oleivora, Aceria sheldoni, Eutetranychus orientalis, Brevipalpus obovatus, T. cinnabarinus; on vegetables:T. cinnabarinus, Tetranychus urticae; on vines:Eriophyes vitis; on pomegranates:Eriophyes granati.

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Résumé Les acariens d'une importance èconomique au Liban, en Jordanie et au sud de la Turquie sont donné avec les dates et les endroits où ils ont ètè trouvés. Sur pommiers on a trouvé:Tetranychus urticae, Metatetranychus ulmi, Tetranychus cinnabarinus, Bryobia rubrioculus; sur agrumes:Phyllocoptruta oleivora, Aceria sheldoni, Eutetranychus orientalis, Brevipalpus obovatus, T. cinnabarinus; sur légumes;Tetranychus urticae, T. cinnabarinus; sur les vignes:Eriophyes vitis; sur les grenades:Eriophyes granati.

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Specific developmental stages of gametogenesis for radiosensitivity and mutagenesis in rice     

Y. Kowyama  T. Saba  T. Tsuji  T. Kawase 《Euphytica》1994,80(1-2):27-38

Summary Developmental stages during gametogenesis of rice were histologically examined in the period from differentiation of reproductive organs to anthesis. Plants were exposed to acute X-rays of 20 Gy. Radiosensitivity and mutation frequency were investigated in relation to the developmental stages of reproductive organs. The most radiosensitive stage, as measured by reduction of the M1 pollen-and seed-fertilities, was the last premeiotic interphase. Mutations induced at different developmental stages were scored in M3 strains. Sterility mutants and short-culm mutants were most frequently observed. Grain shape, panicle morphology, heading-date and endosperm character mutants were induced at a relatively low frequency. The overall mutation frequency varied with the developmental stage at the time of irradiation. The highest overall mutation frequency was observed when radiation was applied 10 days before anthesis, the late tetrad stage of microspores. Radiation exposure of florets at the late tetrad stage was found to be a more efficient method of inducing a large number of mutations than radiations applied to seeds and fertilized egg cells.  相似文献   

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase   总被引：1，自引：0，他引：1  

Du J  Zhou Y  Su X  Yu JJ  Khan S  Jiang H  Kim J  Woo J  Kim JH  Choi BH  He B  Chen W  Zhang S  Cerione RA  Auwerx J  Hao Q  Lin H 《Science (New York, N.Y.)》2011,334(6057):806-809

Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1 to Sirt7. Four of them (Sirt4 to Sirt7) have no detectable or very weak deacetylase activity. We found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro. The preference for succinyl and malonyl groups was explained by the presence of an arginine residue (Arg(105)) and tyrosine residue (Tyr(102)) in the acyl pocket of Sirt5. Several mammalian proteins were identified with mass spectrometry to have succinyl or malonyl lysine modifications. Deletion of Sirt5 in mice appeared to increase the level of succinylation on carbamoyl phosphate synthase 1, which is a known target of Sirt5. Thus, protein lysine succinylation may represent a posttranslational modification that can be reversed by Sirt5 in vivo.  相似文献   

5-Lipoxygenase expression in benign and malignant canine prostate tissues     

Goodman LA  Jarrett CL  Krunkosky TM  Budsberg SC  Northrup NC  Saba CF  LeRoy BE 《Veterinary and comparative oncology》2011,9(2):149-157

5-Lipoxygenase (5-LO) is overexpressed in human prostate carcinomas (PCs), and its inhibition decreases proliferation and induces apoptosis in prostate cancer cell lines. We hypothesized that 5-LO would be overexpressed in canine PC compared with benign prostate tissue and may be important in the pathogenesis of the disease. Immunoblot analysis of canine PC and benign prostatic hyperplasia (BPH) tissues demonstrated 5-LO expression in both. 5-LO immunohistochemical staining was not significantly different within the stromal or epithelial components of canine primary PC, BPH or suppurative prostatitis, suggesting that differential expression of this enzyme does not occur in these conditions. The percentage of tumour cells expressing 5-LO was significantly lower in metastatic PC lesions compared with primary PC (P < 0.0001). This decreased expression may indicate down-regulation or altered expression of the enzyme with progression of canine PC to a metastatic phenotype.  相似文献   

Orthodromic Reciprocating Tachycardia and Heart Failure in a Dog With a Concealed Posteroseptal Accessory Pathway     

Clarke E. Atkins  Ronald Kanter  Kathy Wright  Ziad Saba  Catherine Baty  Cliff Swanson  Stephen Bai  Bruce W. Keene 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1995,9(1):43-49

A 4-month-old male Labrador Retriever was presented for recurrent bouts of pulmonary edema associated with tachycardia. Initial physical examination and echocardiography were unremarkable, and the electrocardiogram revealed only an intraventricular conduction disturbance. Subsequent recordings showed paroxysmal supraventricular tachycardia (SVT) (340 beats/min), which consistently produced pulmonary edema. The supraventricular tachycardia was unresponsive to adenosine, esmolol, and propranolol; was variably and transiently responsive to various vagal maneuvers and precordial thumps; and was always responsive to IV diltiazem. Multiple life-threatening episodes of SVT occurred, however, despite the chronic administration of oral diltiazem, propranolol, and procainamide. Diastolic cardiac dysfunction was documented by Doppler echocardiography and was thought to contribute to the development of pulmonary edema. A subsequent electrophysiologic study confirmed the presence of an atrioventricular posteroseptal accessory pathway that participated in orthodromic reciprocating tachycardia. This pathway was determined to conduct only in the retrograde direction ("concealed accessory pathway"). Intraoperative IV procainamide titration terminated the arrhythmia, which could not be reinduced when procainamide blood concentration approximated 20 μg/dL. Increasing the oral procainamide dose to achieve such plasma concentrations was successful in eliminating orthodromic reciprocating tachycardia, preventing heart failure, and returning Doppler indices of diastolic function to normal.  相似文献   

Bluetongue virus – 23 stimulates inducible nitric oxide synthase expression and nitric oxide production in mononuclear cells of blood and/or regional lymphoid organs     

Channakeshava Sokke Umeshappa  Karam Pal Singh  Roopa Hebbandi Nanjundappa  Rudragouda Channappanavar  Sushila Maan  Narender S. Maan 《Veterinary research communications》2012,36(4):245-250

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Outcome of 19 dogs with parathyroid carcinoma after surgical excision     

Sawyer ES  Northrup NC  Schmiedt CW  Culp WT  Rassnick KM  Garrett LD  Selting KA  Saba CF  Howerth EW 《Veterinary and comparative oncology》2012,10(1):57-64

Parathyroid carcinoma (PTC) is rare in dogs and there is little information documenting its treatment and prognosis. The objective of this study was to describe the outcome of dogs with PTC treated with surgical excision. Medical records of 19 dogs undergoing surgical excision of PTC between 1990 and 2010 were reviewed retrospectively. Dogs were presented for clinical hypercalcaemia or incidental hypercalcaemia noted by referring veterinarians on routine serum chemistry profiles. A parathyroid nodule was identified with cervical ultrasound in 17/17 dogs. Hypercalcaemia resolved in 18/19 dogs within 4 days postoperatively. Nine developed hypocalcaemia. None were confirmed to develop recurrent or metastatic PTC. The only death associated with PTC was a dog that was euthanized for intractable hypocalcaemia 9 days after surgery. Estimated 1-, 2- and 3-year survival rates were 72, 37 and 30%, respectively. Excision of PTC results in resolution of hypercalcaemia and excellent tumour control.  相似文献   

Phase II clinical evaluation of lomustine chemotherapy for feline vaccine‐associated sarcoma     

C. F. Saba  D. M. Vail  D. H. Thamm 《Veterinary and comparative oncology》2012,10(4):283-291

Treatment of feline vaccine‐associated sarcoma (VAS) is challenging, in part due to the high likelihood of tumour recurrence despite aggressive local therapy. Lomustine is potentially an attractive agent to add to the current treatment armamentarium. In this de‐escalating phase I/II prospective trial, 28 cats with measurable VAS were treated at target dosages of 38–60 mg m^?2 every 3 weeks until disease progression. The overall response rate was 25%, with a median progression‐free survival and median duration of response of 60.5 and 82.5 days, respectively. Haematologic toxicity, specifically cumulative neutropenia, was significant, and dose reductions and treatment delays were common. Although these data support further investigation of lomustine for the treatment of VAS, safe, multidosing protocols must first be determined.  相似文献   

Effect of salinity on water stress, growth, and yield of maize and sunflower   总被引：10，自引：0，他引：10  

N. Katerji  J.W. van Hoorn  A. Hamdy  F. Karam  M. Mastrorilli 《Agricultural Water Management》1996,30(3):237-249

Maize and sunflower were grown in tanks filled with loam and clay, and were irrigated with water of three different levels of salinity. Predawn leaf-water potential and stomatal conductance were used as parameters for water stress. The predawn leaf-water potential of maize was higher than that of sunflower, but the effect of salinity and soil texture on the predawn leaf-water potential was the same for both crops. The stomatal conductance of sunflower was much higher and more severely affected by salinity and soil texture than the stomatal conductance of maize.

Although salinity had a more serious effect on the development of leaf area and canopy dry matter of sunflower, its effect on evapotranspiration and grain yield was the same for both crops. Soil texture had a stronger effect on the development of leaf area and canopy dry matter of sunflower, which also appeared in the evapotranspiration and grain yield, indicating that sunflower is more sensitive to drought than maize.  相似文献   

Production of an Antibody Fragment (scFv) Targeting PcrV Protein of Pseudomonas aeruginosa in Fed-Batch Cultivation Mode     

Saba Karam  Mozhgan Raigani  Sahar Hassani Afshar  Yeganeh Talebkhan  Elham Bayat  Samira Komijani  Leila Nematollahi  Farzaneh Barkhordari  Mehdi Shafiee Ardestani  Fatemeh Davami 《Iranian Biomedical Journal》2021,25(6):390

Background: Pseudomonas aeruginosa is one of the opportunistic pathogens causing frequent hospital-acquired life-threatening infections in mechanically ventilated patients. The most significant virulence factor of P. aeruginosa is T3SS. PcrV is an important structural protein of the T3SS. Methods:In the current investigation, a recombinant scFv mAb against the PcrV protein was expressed in EnBase® (fed-batch) cultivation mode. The pETiteTM N-His SUMO Kan vector, including anti-PcrV scFv gene, was transformed into Escherichia coli (BL21) cells. The expression and solubility of anti-PcrV scFv protein were investigated at two different temperatures (25 °C and 30 °C) and at different induction times (4, 6, 8, 12, and 24 hours). Results:Increased efficiency was achieved by EnBase® compared to LB broth; owing to the slow release of glucose, the maximum level of solubility and total protein expression was observed in EnBase® cultivation system at 30 °C and 24 h post induction. Furthermore, IC₅₀ for anti-PcrV scFv protein was determined to be approximately 7 μg/mL. Conclusion:Anti-PcrV scFv produced in this study showed promising in vitro results, protecting RBC from lysis by P. aeruginosa (exoU+). Key Words: Fed Batch, recombinant protein, Pseudomonas aeruginosa, scFv  相似文献